Prisca Liberali

Prisca Liberali has been trained as a physical organic chemist, and during her postdoc she has developed new single-cell methods and statistical approaches to model complex patterns of cell-to-cell variability. Prisca is a senior group leader at the FMI, in which she continues to innovate on image-based single-cell approaches. She has set up novel light-sheet and high-throughput imaging approaches to quantify multiple features of organoid and gastruloid development. This has recently led to a seminal paper by her group showing that initial symmetry breaking in intestinal organoids is determined by variation in mechano-sensing in individual cells. In addition, she has successfully applied this platform to achieve the first high-content screen of compounds that interfere with intestinal regeneration and identified novel compounds that improve intestinal regeneration in vivo. She received the EMBO Gold Medal 2022.

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